Characterization of feline nonsteroidal anti-inflammatory drug activated gene-1 (fNAG-1) and its protective function in kidney cells.

ABSTRACT:

Background

Domestic cats are susceptible to obesity and chronic renal failure, leading to significant health risks. Nonsteroidal anti-inflammatory drug-activated gene (NAG-1), also known as growth differentiation factor 15 (GDF15), is a member of the transforming growth factor-β superfamily and has been associated with anti-obesity properties and preservation of kidney function. While the NAG-1 sequence has been extensively studied in several species, a comprehensive understanding of feline NAG-1 remains limited. This study aimed to investigate the nucleotide sequence of feline NAG-1 and its biological role in kidney protection through in-vitro experiments.

Methods

The feline NAG-1 cDNA was isolated from the feline uterus, and its sequence was analyzed and compared to sequen

SUBMITTER: Lertpatipanpong P 

PROVIDER: S-EPMC12093827 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature