CCDC110 promotes the progression of hepatocellular carcinoma by activating the TGF-β/SMAD signaling pathway through targeted regulation of TGFBR1.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is recognized for its high growth rate, high degree of invasiveness, and tendency to spread, leading to a significant number of deaths. In the course of studying the transcriptome of HCC tissues, the protein coiled-coil domain-containing 110 (CCDC110) was identified. By employing tandem mass tag (TMT) quantitative proteomics, this research identified transforming growth factor beta receptor 1 (TGFBR1) as a potential target influenced by CCDC110. The purpose of this study was to examine the role of CCDC110 in the growth and invasion of HCC and to identify new potential targets for the treatment of HCC.

Methods

In vitro and in vivo experiments were conducted to investigate the role and mechanism of CCDC110 in promoting the malignant be

SUBMITTER: Shen H 

PROVIDER: S-EPMC12093845 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature