GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration.

ABSTRACT:

Background

GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement in inflammatory disorders and cancers. C-X-C chemokine receptor type 4 (CXCR4) plays a critical role in immune cell trafficking and cancer metastasis. Recent evidence suggests a connection between GPR15LG and CXCR4 signaling, which has not been investigated so far.

Methods

We investigated the effects of GPR15LG on CXCR4 signaling and downstream functions. Binding assays and computational modeling were performed to assess the interaction between GPR15LG and CXCR4. Functional assays, including wound healing and cell migration assays, were conducted across various cell type

SUBMITTER: Albers DPJ 

PROVIDER: S-EPMC12093852 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature