Association of myeloid cell reactivity patterns with safe food predictions in FPIES patients.

ABSTRACT:

Background

Food protein-induced enterocolitis syndrome (FPIES) is an understudied non-IgE-mediated food allergy, which is distinct from and lacks diagnostic testing akin to IgE testing. FPIES affects infants and toddlers but can persist into adulthood. As there are no extant methods to identify safe foods for FPIES patients, food ingestion trials are performed at home and often lead to reactions and development of food aversions, which may lead to failure-to-thrive and gastric feeding tube requirements. We hypothesized that foods that fail to elicit responses in immune cells of FPIES patients would be safe to ingest, which could support development of a diagnostic method to headstart safe food identification in patients.

Methods

We developed an ex vivo model of FPIES using f

SUBMITTER: Sanders GM 

PROVIDER: S-EPMC12093898 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature