Impact of Islet Transplantation on Diabetes Complications and Mortality in Patients Living With Type 1 Diabetes.

ABSTRACT:

Objective

This study aimed to evaluate the impact of islet transplantation (IT) on diabetes complications, death, and cancer incidence.

Research design and methods

This retrospective, multicenter, cohort study included patients from three IT clinical trials (intervention group) and from the French health insurance claims database Système National des Données de Santé (SNDS) (control group). Two cohorts of IT recipients were analyzed: IT recipients after kidney transplantation (IAK) and IT recipients alone (ITA). They were matched with patients living with type 1 diabetes (T1D) from the SNDS using a propensity score. The primary outcome was a composite criterion including death, dialysis, amputation, nonfatal stroke, nonfatal myocardial infarction, and transient ischemic atta

SUBMITTER: Perrier Q 

PROVIDER: S-EPMC12094206 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature