Capsid and genome damage are the leading inactivation mechanisms of aerosolized porcine respiratory coronavirus at different relative humidities.

ABSTRACT: Relative humidity (RH) varies widely in indoor environments based on temperature, outdoor humidity, heating systems, and other environmental conditions. This study explored how RH affects aerosolized porcine respiratory coronavirus (PRCV), a model for coronaviruses, over a time range from 0 min to a maximum of 1 h, and the molecular mechanism behind viral infectivity reduction. These questions were answered by quantifying: (i) viral-host receptor interactions, (ii) capsid integrity, (iii) viral genome integrity, and (iv) virus infectivity. We found RH did not alter PRCV-receptor interactions. RHs 45-55% and 65-75% damaged viral genomes (2 log₁₀ reduction and 1 log₁₀ reduction, respectively, in terms of median sample value), whereas RHs 55-65% decreased capsid integrit

SUBMITTER: Zhou A 

PROVIDER: S-EPMC12094281 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature