Enhanced disgust generalization in obsessive-compulsive disorder is related to insula and putamen hyperactivity.

ABSTRACT:

Background

Compulsive cleaning is a characteristic symptom of a particular subtype of obsessive-compulsive disorder (OCD) and is often accompanied by intense disgust. While overgeneralization of threat is a key factor in the development of obsessive-compulsive symptoms, previous studies have primarily focused on fear generalization and have rarely examined disgust generalization. A systematic determination of the behavioral and neural mechanisms underlying disgust generalization in individuals with contamination concern is crucial for enhancing our understanding of OCD.

Method

In this study, we recruited 27 individuals with high contamination concerns and 30 individuals with low contamination concerns. Both groups performed a disgust generalization task while undergoing func

SUBMITTER: Liu J 

PROVIDER: S-EPMC12094653 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature