Characterizing vascular function in mouse models of Alzheimer's disease, atherosclerosis, and mixed Alzheimer's and atherosclerosis.

ABSTRACT:

Significance

Alzheimer's disease does not occur in isolation, and there are many comorbidities associated with the disease, especially diseases of the vasculature. Atherosclerosis is a known risk factor for the subsequent development of Alzheimer's disease; therefore, understanding how both diseases interact will provide a greater understanding of co-morbid disease progression and aid the development of potential new treatments.

Aim

We characterize hemodynamic responses and cognitive performance in APP/PS1 Alzheimer's mice, atherosclerosis mice, and a mixed disease group (APP/PS1 and atherosclerosis) between the ages of 9 and 12 months.

Approach

Whisker-evoked hemodynamic responses and recognition memory were assessed in awake mice, immunohistochemistry to assess amyl

SUBMITTER: Eyre B 

PROVIDER: S-EPMC12094910 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature