MicroRNA-1985 enhances the redox capability of scallop (<i>Patinopecten yessoensis</i>) in response to poly(I:C) stimulation by targeting MNK1.

ABSTRACT: To clarify the microRNA (miRNA)-target gene axis is involved in response to pathogen-associated molecular pattern (PAMP)-induced oxidative stress in shellfish, the full-length cDNA of a novel mitogen-activated protein kinase-interacting kinase 1 (MNK1) homolog gene from the scallop Patinopecten yessoensis (PyMNK1) was cloned and characterized. The interaction between miR-1985 and PyMNK1 was verified, and then the responses and possible molecular function of miR-1985, PyMNK1, and miR-1985/PyMNK1 axis to poly(I:C) (a classic virus-related PAMP) stimulation in P. yessoensis were explored and preliminarily dissected. The results indicate: 1) The full-length cDNA of PyMNK1 was 5354 bp, with a high level of sequence conservation acro

SUBMITTER: Yu L 

PROVIDER: S-EPMC12095029 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature