Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters.

ABSTRACT: Auxins are a group of phytohormones that control plant growth and development. Their crucial role in plant physiology has inspired development of potent synthetic auxins that can be used as herbicides. Phenoxyacetic acid derivatives are a widely used group of auxin herbicides in agriculture and research. Despite their prevalence, the identity of the transporters required for distribution of these herbicides in plants is both poorly understood and the subject of controversial debate. Here we show that PIN-FORMED auxin transporters transport a range of phenoxyacetic acid herbicides across the membrane. We go on to characterize the molecular determinants of substrate specificity using a variety of different substrates as well as protein mutagenesis to probe the binding site. Finally, we prese

SUBMITTER: Schulz L 

PROVIDER: S-EPMC12095047 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature