Optimal fractionation scheme for lymphocyte infiltration in glioblastoma multiforme radiotherapy.

ABSTRACT:

Purpose

Radioresistant and immunosuppressive tumors, such as glioblastoma multiforme (GBM), remain a challenge, as current clinical approaches-surgical resection and chemoradiation-do not yet provide effective treatment. Immunotherapy (IT) has emerged as a powerful tool in cancer; however, phase III clinical trials in GBM have yielded unsuccessful results, likely due to its critical dependence on preexisting antitumor immunity. Given its immunomodulatory potential, radiotherapy (RT) could serve as a tool to induce tumor inflammation and enhance responsiveness to IT. However, the optimal radiation configuration required to achieve the critical level of tumor inflammation for IT success remains elusive. This study assessed the most effective dose fractionation scheme fo

SUBMITTER: Iturri L 

PROVIDER: S-EPMC12095198 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature