Investigation of <i>Fructus sophorae extract</i>'s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation.

ABSTRACT:

Objective

This study systematically elucidates the therapeutic mechanism of Fructus sophorae extract (FSE) against atrophic vaginitis (AV) by integrating network pharmacology with in vitro experimental validation.

Methods

Potential drug targets of FS and AV-related disease targets were systematically retrieved from TCMSP, SWISS Target Prediction, GeneCards, and DisGeNET databases. The putative therapeutic targets of FS against AV were identified through target overlap analysis between drug and disease targets. Functional enrichment analyses of GO terms, KEGG pathways, and disease associations were performed using DAVID database, with results visualized by Cytoscape software. Molecular docking validation and binding affinity visualization between FS components a

SUBMITTER: Zheng J 

PROVIDER: S-EPMC12095276 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature