Arginine methylation patterns in LUAD: defining prognostic subtypes and relevance to immunotherapy.

ABSTRACT:

Background

Lung cancer remains the leading cause of cancer-related death worldwide, with lung adenocarcinoma (LUAD) being the most common subtype. Arginine methylation, driven by protein arginine methyltransferases (PRMTs) has been connected to cancer biology, particularly in modulating cancer immunity. Thus, developing a PRMTs-related prognostic model might help create more personalized treatment plans for LUAD patients.

Methods

We conducted an integrative analysis using multi-omics data from LUAD samples within the TCGA and GEO database, focusing on the expression profiles of nine PRMTs. Employing machine learning, we developed a PRMTs-related prognostic model, to evaluate the clinical and immunological features of LUAD patients.

Results

We stratified 440 LUAD patie

SUBMITTER: Shen Q 

PROVIDER: S-EPMC12095734 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature