Sequential macrophage DENV and ZIKV infection shows differential expression of CD86, IFN-β, and regulation of TNF-α and IL-1β depending on DENV serotype.

ABSTRACT: Dengue virus (DENV) is an RNA virus belonging to the Flaviviridae family, comprising four antigenically distinct serotypes. Dengue is the primary arthropod-transmitted virus globally, posing a significant public health challenge, especially in Brazil, where the largest outbreak of Zika virus (ZIKV) was also recorded in 2016. ZIKV shares genomic and structural similarities with DENV, and their co-circulation in Brazil provides evidence of co-infection. The innate immune response against DENV and ZIKV is mediated by pattern recognition receptors that initiate intracellular signaling, leading to antiviral or inflammatory responses. This study aims to better understand the innate immune response to ZIKV in macrophages previously infected with DENV. To achieve this, bone marrow cells from C57BL

SUBMITTER: Brancaglion GA 

PROVIDER: S-EPMC12095828 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature