The Fsr transporter of <i>Sinorhizobium meliloti</i> contributes to antimicrobial resistance and symbiosis with alfalfa.

ABSTRACT: Major facilitator superfamily (MFS) transporters in bacteria participate in both the uptake and export of ions, metabolites or toxic compounds. In rhizobia, specific MFS transporters increase resistance to plant-produced compounds and may also affect other phenotypic traits, including symbiosis with legume host plants. Here, we describe the importance of the Sinorhizobium meliloti 1021 Fsr efflux pump in resistance to selected antimicrobial compounds and in modulating biofilm formation, motility and symbiotic efficiency with alfalfa. The fsr gene (smc00990) is annotated as encoding an MFS family fosmidomycin efflux pump. Unexpectedly, both the 1021 wild type and an fsr null mutant were highly resistant to fosmidomycin. Our assays indicate that this is due to an

SUBMITTER: Chavez-Jacobo VM 

PROVIDER: S-EPMC12095868 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature