Phenotyping the responses to systemic corticosteroids in the management of asthma attacks (PRISMA).

ABSTRACT:

Background

Asthma attacks are heterogeneous. It is not known whether the response to oral corticosteroids (OCS) in acute asthma varies according to type 2 (T2) inflammatory biomarkers, blood eosinophil count (BEC) and fractional exhaled nitric oxide (F _ENO). We aimed to explore the relationship between T2 biomarkers and response to OCS in acute asthma.

Methods

We conducted a longitudinal observational study of people experiencing an asthma attack evaluated before and after a 7-day OCS course. The primary outcome was post-bronchodilator change in forced expiratory volume in 1 s (FEV₁) according to ordinal BEC-F _ENO three-group categories (T2-Low/Low: BEC <0.15×10⁹ cells·L^-1 and F _ENO <25 pp

SUBMITTER: Celis-Preciado C 

PROVIDER: S-EPMC12095907 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature