Development and validation of an ARID1A-related immune genes risk model in evaluating prognosis and immune therapeutic efficacy for gastric cancer patients: a translational study.

ABSTRACT:

Background

Mutations in the ARID1A gene, an integral component of the SWI/SNF complex, are prevalent, affecting prognosis and immune response in several malignancies, including gastric cancer (GC). The aim of this study was to identify ARID1A mutation-associated immune genes to construct an ARID1A-related immune gene risk model (ARM).

Methods

GSEA and ssGSEA were used to explore the involved biological pathways and the degree of immune cell infiltration, respectively. The prognosis model was constructed by lasso-COX. Protein expression level in tissue was verified by immunohistochemistry. Small molecule compounds were screened using molecular docking techniques and their anticancer value was validated in vitro and in vivo experiment.

Results

This study r

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12096169 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature