Innovative Silica-Supported Acid Catalyst for Sustainable Synthesis of Bioactive Pyrazoles: Insights into Mechanisms and Applications.

ABSTRACT: An innovative silica-bonded N-(propylaminobenzene)-sulfonic acid (SBPASA) catalyst was synthesized by immobilizing metanilic acid onto silica and characterized using advanced techniques, including FTIR, XRD, SEM/EDX, Raman spectroscopy, UV-visible analysis, and BET surface area analysis. The catalyst exhibited a high surface area of 306.9 m²/g, an optimal mesoporous diameter of 31.4 Å, and high product yields (up to 98%), distinguishing it from previously reported silica-supported catalysts. This catalyst facilitated the efficient preparation of 4,4'-(arylmethylene)-bis-(1H-pyrazol-5-ols) (4a-i) in a solvent-free environment, resulting in high yields with a variety of functional groups. The silica surface played a critical role in facilitating key rea

SUBMITTER: Aslam A 

PROVIDER: S-EPMC12096245 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature