Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events.

ABSTRACT:

Importance

Peripheral artery disease (PAD) is a heritable atherosclerotic condition associated with functional decline and high risk for limb loss. With growing knowledge of the genetic basis for PAD and related risk factors, there is potential opportunity to identify individuals at high risk using polygenic risk scores (PRSs).

Objective

To develop a novel integrated, multiancestry polygenic score for PAD (PRS-PAD) and evaluate its risk estimation for PAD and major adverse limb events in 3 populations.

Design, setting, and participants

This longitudinal cohort study was conducted among individuals with genotyping and electronic health record data in the UK Biobank (2006-2021), All of Us (AoU, 2018-2022), and the Mass General Brigham Biobank (MGBB, 2010-2023). Data wer

SUBMITTER: Flores AM 

PROVIDER: S-EPMC12096330 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature