Obligately Tungsten-Dependent Enzymes─Catalytic Mechanisms, Models and Applications.

ABSTRACT: Tungsten-dependent enzymes incorporate a tungsten ion into their active site in the form of a complex with two pyranometallopterin (MPT) molecules, also known as tungsten cofactor (W-co). W-co-containing enzymes are found in several bacteria and archaea, predominantly in enzymes involved in anaerobic metabolism. While some enzymes occur with either molybdenum or tungsten in their active sites, we concentrate here on enzymes obligately depending on W-co, which are not functional as isoenzymes with Mo-co. These are represented by several subtypes of aldehyde oxidoreductases (AORs), class II benzoyl-CoA reductase (BCRs) and acetylene hydratase (AHs). They catalyze either low-potential redox reactions or the unusual hydration reaction of acetylene. In this review, we analyze the catalytic and

SUBMITTER: Szaleniec M 

PROVIDER: S-EPMC12096430 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature