Development of a Japanese polygenic risk score model for amyloid-β PET imaging in Alzheimer's disease.

ABSTRACT:

Background

The use of polygenic risk scores (PRS) for predicting disease risk in Japanese populations, particularly for dementia and related phenotypes, remains markedly unexplored. The aim of this study was to bridge this gap by developing a novel PRS model designed to predict amyloid-β (Aβ) deposition utilizing positron emission tomography (PET) imaging data from a Japanese cohort.

Methods

Using the polygenic risk score-continuous shrinkage (PRS-CS) algorithm, we calculated PRS based on significant single nucleotide polymorphisms (SNPs) associated with Alzheimer's disease (AD) in this population. We applied a PRS calculation approach informed by Japanese genome-wide association studies (GWAS) summary statistics into a Japanese dementia cohort from Keio University.

Resul

SUBMITTER: Kaishima M 

PROVIDER: S-EPMC12096521 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature