Anti-inflammatory polyketides from <i>Santalum album</i> derived endophytic fungus <i>Hypomontagnella</i> sp. TX-09.

ABSTRACT: Four new lactones, including hypomonacid A (1) and hypomonone A-C (4-6), as well as nine known polyketide analogues (2-3 and 7-13) were obtained from endophytic fungus Hypomontagnella sp. TX-09 derived from Santalum album. Their planar structures were extensively established by analysing HRESIMS and NMR spectroscopic data. Stereochemistry of new compounds was determined by X-ray diffraction analysis and modified Mosher's method in combination with quantum-chemical ECD calculation. In addition, compounds 1 and 2 showed anti-inflammatory activity by inhibition of lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells at 50 μmol/L without cytotoxicity. Among them, compound 1 inhibited the production of LPS-stimulated inf

SUBMITTER: Ouyang X 

PROVIDER: S-EPMC12096673 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature