Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing.

ABSTRACT:

Background

Type 2 diabetes is an increasingly prevalent metabolic disorder with moderate to high heritability. Glycemic indices are crucial for diagnosing and monitoring the disease. Previous genome-wide association study (GWAS) have identified several risk loci associated with type 2 diabetes, but data from the Taiwanese population remain relatively sparse and primarily focus on type 2 diabetes status rather than glycemic trait levels.

Methods

We conducted a comprehensive genome-wide meta-analysis to explore the genetics of glycemic traits. The study incorporated a community-based cohort of 145,468 individuals and a hospital-based cohort of 35,395 individuals. The study integrated genetics, transcriptomics, biological pathway analyses, polygenic risk score calculation, and

SUBMITTER: Lin MR 

PROVIDER: S-EPMC12096723 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature