SloR-SRE binding to the <i>S. mutans mntH</i> promoter is cooperative.

ABSTRACT: Streptococcus mutans is a commensal member of the plaque microbiome. It is especially prevalent when dietary sugars are available for S. mutans fermentation, generating acid byproducts that lower plaque pH and foster tooth decay. S. mutans can survive in the transient conditions of the mouth, in part because it can regulate the uptake of manganese and iron during periods of feast when metal ions are available, and famine when they are limited. S. mutans depends on a 25kDa metalloregulatory protein, called SloR, to modulate the uptake of these cations across the bacterial cell surface. When bound to manganese, SloR binds to palindromic recognition elements in the promoter of the sloABC genes that encode the major manganese transporter in S. mutans. Reports

SUBMITTER: Ziogas M 

PROVIDER: S-EPMC12096823 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature