Defining the networks that connect RNase III and RNase J-mediated regulation of primary and specialized metabolism in <i>Streptomyces venezuelae</i>.

ABSTRACT: RNA metabolism involves coordinating RNA synthesis with RNA processing and degradation. Ribonucleases play fundamental roles within the cell, contributing to the cleavage, modification, and degradation of RNA molecules, with these actions ensuring appropriate gene regulation and cellular homeostasis. Here, we employed RNA sequencing to explore the impact of RNase III and RNase J on the transcriptome of Streptomyces venezuelae. Differential expression analysis comparing wild-type and RNase mutant strains at distinct developmental stages revealed significant changes in transcript abundance, particularly in pathways related to multicellular development, nutrient acquisition, and specialized metabolism. Both RNase mutants exhibited dysregulation of the BldD regulon, including altered ex

SUBMITTER: Pepler MAD 

PROVIDER: S-EPMC12096830 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature