Genetic Causal Relationship Between Systemic Lupus Erythematosus and Malignant Tumors of the Female Reproductive System: A GWAS Analysis in European Populations.

ABSTRACT: Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that primarily affects women of reproductive age. Existing studies have demonstrated complex associations between SLE and various diseases, but its genetic relationship with malignant tumors of the female reproductive system has not been fully elucidated. This study is aimed at exploring the potential genetic associations and shared molecular basis between SLE and female reproductive system malignancies using genome-wide association studies (GWASs) and cross-trait analysis. Methods: We selected genetic variants significantly associated with SLE (p < 5 × 10^-8) from large-scale GWAS databases as genetic instruments and applied various statistical methods to analyze the associati

SUBMITTER: Li J 

PROVIDER: S-EPMC12097853 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature