High-Density Lipoproteins Associated with Age-Related Macular Degeneration in the All of Us Research Program.

ABSTRACT:

Purpose

Extracellular lipoprotein aggregation is a critical event in age-related macular degeneration (AMD) pathogenesis. In this study, we sought to analyze associations between clinical and genetic-based factors related to lipoprotein metabolism and risk for AMD in the All of Us research program.

Design

Cross-sectional retrospective data analysis.

Participants

A total of 5028 healthy participants and 2328 patients with AMD from All of Us.

Methods

Participants with and without AMD were age, race, and sex matched in a 1:2 ratio, respectively. Smoking status, history of hyperlipidemia, and statin use were extracted in a binary manner. Statin use was further subcategorized into hepatically versus nonhepatically metabolized statins. Laboratory values for low-densi

SUBMITTER: Chen JS 

PROVIDER: S-EPMC12097936 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature