Immune inflammatory regulation in Anti-NMDAR encephalitis: insights from transcriptome analysis.

ABSTRACT:

Background

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a critical neurological disorder mediated by autoimmune mechanisms, Previous literature suggests that immune inflammatory responses may be involved in the progression of anti NMDAR encephalitis, but its molecular regulatory mechanisms still remain uncertain. We aimed to identify transcriptome-wide landscape of mRNAs and explore the potential pathogenesis for anti-NMDAR encephalitis.

Methods

Peripheral blood mononuclear cells were obtained from six patients with anti-NMDAR encephalitis and six controls for RNA extraction and library creation. The Illumina HiSeq platform was used to do transcriptome sequencing. We utilized R software to identify differentially expressed genes (DEGs) and performed a functiona

SUBMITTER: Qiao S 

PROVIDER: S-EPMC12098042 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature