Multicenter analysis of high-dose chemotherapy regimens for the treatment of patients with refractory or recurrent germ cell tumors.

ABSTRACT:

Background

High-dose chemotherapy (HDCT) is an established salvage treatment for recurrent germ cell tumors (GCTs). Comparative analyses of contemporary carboplatin-based HDCT regimens are limited. This study provides a multicenter analysis of commonly used regimens.

Patients and methods

Data from four referral centers included patients treated with HDCT for recurrent GCTs between January 2010 and January 2024. Fisher's exact test and the Wilcoxon rank sum test were used for statistical analyses. Kaplan-Meier and log-rank tests assessed relapse-free survival (RFS) and overall survival (OS).

Results

Among 111 patients (median age 28.5 years), 76.6% had non-seminomatous GCT, and 43.2% had poor-risk disease per the International Germ Cell Cancer Collaborative Group (IGCC

SUBMITTER: Chehrazi-Raffle A 

PROVIDER: S-EPMC12098135 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature