Genomic analysis elucidates characteristics and possible origins of high-risk antimicrobial resistance genes in <i>Enterococcus faecium</i> from a global perspective.

ABSTRACT: Under the One Health framework, it is crucial to undertake a comprehensive analysis of antimicrobial resistance (AMR) across various countries and regions. High-risk ARGs pose a severe threat to human health, yet systematic research on them is scarce. This study developed a high-risk ARGs database using the existing risk assessment system and explored a genome-based investigation workflow for high-risk ARGs. We investigated Enterococcus faecium, a common clinical pathogen, to understand the epidemiological characteristics of high-risk ARGs, including their primary sources and destinations. Results revealed that high-risk ARGs are widespread in E. faecium, with tet(M) being the most abundant and ermB the most widely distributed. The combination of vancomycin_ARGs

SUBMITTER: Mu C 

PROVIDER: S-EPMC12098168 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature