Integrating Mendelian randomization and multi-transcriptomic analyses to unveil the genetic association risk of regulatory T cell-mediated free cholesterol and gastric cancer.

ABSTRACT:

Background

Evidence from observational studies suggests an association between free cholesterol and gastric cancer. Immune cells play a crucial role in the tumor microenvironment of gastric cancer, and free cholesterol can influence immune cells in various ways, thereby impacting gastric cancer. The mechanisms by which free cholesterol regulates and activates the immune response to exert antitumor effects, as well as the causal relationship between free cholesterol and gastric cancer, remain unclear.

Methods

We employed a two-sample Mendelian randomization (MR) approach to investigate the causal relationship between 233 metabolites and gastric cancer. Additionally, we validated our findings using data from GWAS databases of similar traits. Using publicly available genetic da

SUBMITTER: Peng F 

PROVIDER: S-EPMC12098249 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature