Construction of lung adenocarcinoma subtype and prognosis model based on fatty acid metabolism-related genes.

ABSTRACT:

Objective

To explore the role of genes related to fatty acid metabolism in lung adenocarcinoma classification and prognosis.

Methods

Transcriptome and clinical data from the TCGA database and GEO database were collected, the expression of prognostic fatty acid metabolism-related genes in LUAD patients was analyzed, and key genes related to both fatty acid metabolism and subtype were identified. These key genes were further filtered via the LASSO regression method, and the retained genes were used to construct a risk-scoring model. The biological function of RPS4Y1 was verified by cell viability, colony formation, migration, and flow cytometry assays. Finally, immune infiltration and drug sensitivity were analyzed in the high- and low-risk groups.

Results

31 key FAMGs

SUBMITTER: Chen J 

PROVIDER: S-EPMC12098254 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature