Analysing protein complexes in plant science: insights and limitation with AlphaFold 3.

ABSTRACT: AlphaFold 3 (AF3), an artificial intelligence (AI)-based software for protein complex structure prediction, represents a significant advancement in structural biology. Its flexibility and enhanced scalability have unlocked new applications in various fields, specifically in plant science, including improving crop resilience and predicting the structures of plant-specific proteins involved in stress responses, signalling pathways, and immune responses. Comparisons with existing tools, such as ClusPro and AlphaPulldown, highlight AF3's unique strengths in sequence-based interaction predictions and its greater adaptability to various biomolecular structures. However, limitations persist, including challenges in modelling large complexes, protein dynamics, and structures from underrepresented

SUBMITTER: Lin PY 

PROVIDER: S-EPMC12098255 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature