Genomic analysis of community-associated methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) causing infections in children-a Spanish multicenter study.

ABSTRACT:

Objectives

Staphylococcus aureus is one of the most common human pathogens causing skin and soft tissue infections (SSTIs) among children. This study investigated the molecular traits of community-associated methicillin-resistant S. aureus (CA-MRSA) isolates causing infections in children in Spain.

Methods

Antibiotic susceptibility testing and whole-genome sequencing were performed in 98 CA-MRSA isolates (4.2 median age, 52% males). The phylogenetic relationship, antibiotic resistance, virulence, and plasmid replicon genes content were investigated.

Results

Resistance rates were found as follows: Erythromycin, 42.9%, which could be explained due to the presence of erm(C), mph(C), and msr(A) genes; tobramycin, 27.5%, which could be ex

SUBMITTER: Garcia-Cobos S 

PROVIDER: S-EPMC12098397 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature