Clinicopathological features and genetic mutation spectrum of primary anastomosing hemangioma arising from the kidney.

ABSTRACT:

Background

Renal anastomosing hemangioma (RAH) is a rare benign renal tumor, and its clinicopathologic characteristics and genetic mutation spectrum related to its mechanisms of pathogenesis are unclear.

Methods

We carried out whole-genome sequencing (WGS) on RAH samples to explore the genetic mutation spectrum and verified the results by Sanger sequencing. Immunohistochemical analysis was also performed to reveal the histopathological characteristics and the tumor microenvironment components. Moreover, a population-based study was conducted after searching the PubMed, EMBASE, and Ovid SP databases to systematically summarize the clinicopathologic features of patients with RAH.

Results

WGS analysis revealed 10532 somatic single-nucleotide variants (SNVs), 6705 somatic

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12098607 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature