Salivary mycobiome alterations in HIV-infected MSM: dominance of <i>Pseudogymnoascus</i> and functional shifts across disease stages.

ABSTRACT:

Background

Oral health is increasingly recognized as a crucial determinant of overall health in people living with HIV/AIDS (PLWHA). Specifically, the oral mycobiome may play a pivotal role in HIV-associated oral complications. However, the fungal species involved and their potential as biomarkers for HIV-related oral conditions remain poorly understood. This study investigates salivary fungal profiles in PLWHA who have sex with men (MSM), focusing on diversity, functional shifts, and correlations with disease progression.

Methods

A cross-sectional study included 25 MSM participants divided into five groups: HIV-negative controls (n = 5) and four HIV-positive groups stratified by CD4 count: Stage 0 (HIV RNA-positive/antibody-negative; n = 5), Stage 1 (CD4 ≥500 cells/μL; n =

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12098618 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature