Aducanumab delivery via focused ultrasound-induced transient blood-brain barrier opening in vivo.

ABSTRACT: Focused ultrasound (FUS) with magnetic resonance imaging (MRI) guidance (MRgFUS) has emerged as a promising technique for enhancing drug delivery to the brain. Through the controlled oscillation of gas-encased microbubbles, FUS temporarily modulates the integrity of tight junctions, inducing localized blood-brain barrier disruption (BBBD) and allowing targeted drug passage. Aducanumab (ADU) has demonstrated efficacy in reducing amyloid pathology, yet its clinical application remains limited by the restrictive nature of the blood-brain barrier (BBB). This in vivo study aimed to evaluate the efficiency of ADU delivery facilitated by FUS-induced BBBD in the normal Institute of Cancer Research (ICR) mouse brain under two pressure conditions: 0.25 and 0.42 MPa. Following FUS sonication with MRI

SUBMITTER: Jeong J 

PROVIDER: S-EPMC12098756 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature