SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation.

ABSTRACT: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have been increasingly recognized for their potential neuroprotective properties. Nevertheless, their effects on intracerebral hemorrhage (ICH) are still debated, with the precise mechanisms involved remaining unclear. Recent studies indicate that these inhibitors might lower ICH risk through anti-inflammatory mechanisms. This study analyzed genome-wide association study (GWAS) data from individuals of European ancestry, focusing on the relationship between 92 inflammatory biomarkers and ICH. A two-sample, two-step Mendelian randomization (MR) approach was used to examine the potential connection between SGLT-2 inhibition and ICH, as well as to investigate whether inflammatory biomarkers mediate this relationship. Genetic proxies for SGLT-

SUBMITTER: Huang M 

PROVIDER: S-EPMC12098824 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature