Immune-related hub genes and their role in psoriasis pathogenesis.

ABSTRACT: Psoriasis is a prevalent inflammatory skin disorder with immune-related mechanisms that remain incompletely understood. To elucidate the immune landscape of psoriasis, we analyzed expression profiles to identify 115 psoriasis susceptibility genes (PSGs) and subsequently pinpointing eight immune-related hub genes (IRHGs). A predictive model incorporating these IRHGs demonstrated promising prognostic potential for psoriasis. Additionally, extensive intercellular communication was observed among keratinocytes, dendritic cells, monocytes, and T cells. The cellular differentiation trajectory revealed a complex interplay among various cell types and states, highlighting genes such as CXCL8, CCL2, STAT3, and STAT1 emerging as closely associated with the cellular composition and functional status

SUBMITTER: Yin T 

PROVIDER: S-EPMC12098866 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature