MiR-485-3p/MELK cascade mediates tumor progression in pancreatic cancer.

ABSTRACT: Pancreatic cancer remains one of the leading causes of mortality worldwide, largely due to the limitations of current clinical strategies for its treatment. As a result, identifying genetic alterations and potential therapeutic targets could offer new opportunities for improving the diagnosis and treatment of pancreatic cancer. The identification of differentially expressed genes (DEGs) and subsequent analyses, including signaling pathway enrichment, functional classification, and protein-protein interaction (PPI) network construction, were conducted using three public datasets: GSE32676, GSE71989, and GSE16515. Kaplan-Meier survival curves and receiver operating characteristic (ROC) curves were employed to investigate the correlation between hub genes and clinicopathological features in p

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12098867 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature