Prediction of neuroblastoma prognosis with a novel T-cell exhaustion-related gene signature.

ABSTRACT: Neuroblastoma (NB) is the most common type of pediatric extra-cranial tumor that arises in the sympathetic nervous system. The heterogeneity of T-cell exhaustion (TEX) has been linked to the determination of distinct clinical outcomes and the effectiveness of immunotherapy in numerous adult malignancies. Therefore, studying the heterogeneous TEX landscape in NB as well as its impact on clinical outcomes is meaningful. The gene expression and clinical datasets of the Sequencing Quality Control (SEQC), E-MTAB-8248, and Therapeutically Applicable Research to Generate Effective Treatments (TARGET) cohorts were downloaded from publicly available databases. Two TEX-related clusters for neuroblastoma were identified in the SEQC cohort. Patients in TEX-C1 exhibited superior overall survival (OS) a

SUBMITTER: Chen J 

PROVIDER: S-EPMC12098910 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature