A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF), the most common cardiac arrhythmia, has been linked to numerous loci identified by genome-wide association studies (GWAS). However, the causal genes and underlying mechanisms remain unclear.

Methods

We conducted a cross-tissue transcriptome-wide association studies (TWAS) using the unified test for molecular signatures (UTMOST), integrating genetic data from the FinnGen R11 cohort (287 805 individuals) with gene expression profiles from the genotype-tissue expression (GTEx) project. To enhance reliability, we applied functional summary-based imputation (FUSION), fine-mapping of causal gene sets (FOCUS), and multi-marker analysis of GenoMic annotation (MAGMA) for gene prioritization, followed by Mendelian randomization (MR) and colocalizat

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC12099065 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature