Brain derived neurotrophic factor and secreted amyloid precursor protein-α response to moderate and high intensity exercise.

ABSTRACT: Brain-derived neurotrophic factor (BDNF) and secreted amyloid precursor protein-alpha (sAPPα) promote neuronal growth but are lower in people with Alzheimer's Disease (AD). BDNF increases after exercise, but the response may vary with exercise intensity and across blood fractions. While sAPPα rises post-exercise in animals, its response to aerobic exercise in humans is unclear. This study examined how BDNF and sAPPα respond to moderate and high-intensity exercise in healthy young adult humans. Participants completed three exercise conditions: moderate (65% Watt maximum, 30 min), clinical-HIIT (4 × 4 min, 90% Watt maximum), and all-out-HIIT (8 × 30 s, 150% Watt maximum). Blood-based biomarkers were extracted from venous blood drawn from venepuncture at baseline, immediately after exercise,

SUBMITTER: Spencer FSE 

PROVIDER: S-EPMC12099066 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature