Risk of stroke under disease modifying therapies for multiple sclerosis: a systematic review.

ABSTRACT:

Background

Epidemiological research indicates a heightened incidence of cerebrovascular disorders among patients with multiple sclerosis (MS).

Objectives

The aim of the present systematic review was to investigate the potential association between disease modifying therapies (DMTs) and the risk of stroke in MS patient populations.

Data sources and methods

A systematic literature search was performed in MEDLINE and SCOPUS databases up to April 6, 2024, to identify randomized-controlled clinical trials (RCT), registry-based and cohort-studies, case-series, and case-reports reporting on acute ischemic stroke (AIS) or intracerebral hemorrhage (ICH) in MS patients under different DMTs.

Results

Twenty-one studies were included: 1 RCT, 6 registry-based or cohort studi

SUBMITTER: Stefanou MI 

PROVIDER: S-EPMC12099087 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature