Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging.

ABSTRACT: Vascular inflammatory aging is strongly associated with multimorbidity, including immunosenescence. Here, bioinformatic analysis indicated elevated expression of the lysozyme (LYZ) gene in age-dependent vascular diseases. Lyz1 deficiency led to vascular inflammatory aging, including damage to indicators related to oxidative stress, vascular function, and inflammation in the serum and vascular tissues of wild-type (WT) and Lyz1^-/- mice. The 16S ribosomal RNA sequencing of intestinal contents revealed increased Bifidobacterium and its metabolism of acetate, butyrate, omega-muricholic acid, propionate, and valeric acid in Lyz1^-/- mice compared with that in WT mice. Additionally, RNA sequencing of vascular tissues identified differentially expr

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12099208 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature