Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): Protocol for Predictive Validation Study and Randomized Controlled Trial.

ABSTRACT:

Background

Weight loss is a cornerstone of obesity treatment and diabetes mellitus type 2 (T2D) prevention, but its implementation in clinical practice is limited by its perceived burden and variability in response. Personalizing interventions to increase their success rate is an unmet clinical need.

Objective

Identification of predictive factors associated with successful weight loss after sequential exercise in women with obesity.

Methods

The study will consist of a 2-stage analytical approach, including a predictive validation study and a 2:1 randomized cross-over controlled trial. Women aged 25-45 years with obesity (BMI>30) will be included in the study. The intervention will consist of a progressive protocol of aerobic exercise on a treadmill and a bicycle ergom

SUBMITTER: Ludlova M 

PROVIDER: S-EPMC12099273 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature