Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria.

ABSTRACT: The recent global pandemic illustrates the importance of understanding the host cellular infection processes of emerging zoonotic viruses. Nipah virus (NiV) is a deadly zoonotic biosafety level 4 encephalitic and respiratory paramyxovirus. Our knowledge of the molecular cell biology of NiV infection is extremely limited. This study identified changes in cellular components during NiV infection of human cells using a multi-platform, high-throughput transcriptomics, proteomics, lipidomics, and metabolomics approach. Remarkably, validation via multi-disciplinary approaches implicated viral glycoproteins in enriching mitochondria-associated proteins despite an overall decrease in protein translation. Our approach also allowed the mapping of significant fluctuations in the metabolism of glucose

SUBMITTER: Johnston GP 

PROVIDER: S-EPMC12100452 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature