Decoding herbal combination models through systematic strategies: insights from target information and traditional Chinese medicine clinical theory.

ABSTRACT: Traditional Chinese medicine (TCM) utilizes intricate herbal formulations that exemplify the principles of compatibility and synergy. However, the rapid proliferation of herbal data has resulted in redundant information, complicating the understanding of their potential mechanisms. To address this issue, we first established a comprehensive database that encompasses 992 herbs, 18 681 molecules, and 2168 targets. Consequently, we implemented a multi-network strategy based on a core information screening method to elucidate the highly intertwined relationships among the targets of various herbs and to refine herbal target information. Within a non-redundant network framework, separation and overlap analysis demonstrated that the networking of herbs preserves essential clinical information, i

SUBMITTER: Wang M 

PROVIDER: S-EPMC12100621 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature