Investigating the potential scabicidal activities of three essential oils: gaining mechanistic insights through in vitro contact bioassay and molecular docking.

ABSTRACT:

Background

Scabies, sarcoptic itch, is a highly contagious and pruritic skin inflammation. Given their ecological benefits and previous therapeutic properties, essential oils are worth investigating as potentially safer alternatives to synthetic anti-scabies agents.

Objectives

This study aimed to evaluate the effectiveness of three essential oils derived from cassia barks, myrrh oleo-gum-resin, and fennel fruits against Sarcoptes scabiei (Linnaeus, 1758), the causative agent of scabies, using lemongrass and clove essential oils as standards. Additionally, the study explored the structure-activity relationship by characterizing the chemical compositions of these essential oils. Further, a molecular docking study was performed to get further insights into the mechanism of the

SUBMITTER: Wahman R 

PROVIDER: S-EPMC12100822 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature