Causal role of immune cells in primary liver cancer: a mendelian randomization study.

ABSTRACT:

Background

Primary liver cancer is one of the most common fatal malignancies worldwide. Observational studies have shown that immune cells are closely linked to primary liver cancer, however, due to issues like reverse causality and confounding variables, the causal direction and extent of this association remain unclear. Thus, this study aimed to explore the potential causal association between immune cells and primary liver cancer, encompassing hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).

Methods

A two-sample mendelian randomization (MR) analysis was performed using summary statistics from genome-wide association studies (GWAS) of the 731 immune traits and primary liver cancer. The primary liver cancer dataset consisted of a total of 456,348 su

SUBMITTER: Liu J 

PROVIDER: S-EPMC12100895 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature